HCID 11132825, compound → {[(1,3-Thiazol-2-yl)amino]methylene}bis(phosphonic acid)

HRID 345279Notes

Reaction equation

HRID 345279 reaction equation
C([O:3][P:4]([CH:9]([NH:18][C:19]1[S:20][CH:21]=[CH:22][N:23]=1)[P:10]([O:15]CC)(=[O:14])[O:11]CC)(=[O:8])[O:5]CC)C>Cl>[S:20]1[CH:21]=[CH:22][N:23]=[C:19]1[NH:18][CH:9]([P:4]([OH:8])(=[O:3])[OH:5])[P:10]([OH:14])(=[O:11])[OH:15]

Participants

3

Reactant 1

HCID 11132825HCID 11132825, compound

Product 1

HCID 405391{[(1,3-Thiazol-2-yl)amino]methylene}bis(phosphonic acid)

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6.57 g (17 mmol) of 1-(thiazol-2-ylamino)-methane-1,1-diphosphonic acid tetraethyl ester are dissolved in 70 ml of N hydrochloric acid and heated under reflux for 6 hours. In the course of the reaction, the product separates out in the form of a fine white precipitate. After cooling to room temperature, filtration is carried out and the product is washed with aqueous methanol. 4.33 g (93% of the theoretical yield) of 1-(thiazol-2-ylamino)methane-1,1-diphosphonic acid of m.p. 275° (decomposition) are obtained.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 6 hours
  3. customIn the course of the reaction
  4. filtrationfiltration
  5. washthe product is washed with aqueous methanol

Sources & evidence

ORD record
ord-6ab2638744444eb6a9463d566b522173
Source dataset
uspto-grants-1991_10
Patent number
US05057505

Reaction notes

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