Hydrochloric Acid → HCID 10469336, compound

Participants

Reaction Steps

1.97 g (4.9 mmol) of 1-(5-methylthiazol-2-ylamino)methane-1,1-diphosphonic acid tetraethyl ester are heated under reflux in 20 ml of N hydrochloric acid for 6 hours. Upon cooling and leaving the reaction mixture to stand at room temperature, the product crystallises. It is filtered and washed with acetone and petroleum ether. Yield: 0.64 g (45% of the theoretical yield) of 1-(5-methylthiazol-2-ylamino)-methane-1,1-diphosphonic acid of m.p. 208° (decomposition).

Provenance & Evidence