Hydrochloric Acid → HCID 10469336, compound

HRID 345282Notes

Reaction equation

HRID 345282 reaction equation
C([O:3][P:4]([CH:9]([NH:18][C:19]1[S:20][C:21]([CH3:24])=[CH:22][N:23]=1)[P:10]([O:15]CC)(=[O:14])[O:11]CC)(=[O:8])[O:5]CC)C.Cl>>[CH3:24][C:21]1[S:20][C:19]([NH:18][CH:9]([P:10]([OH:14])(=[O:11])[OH:15])[P:4]([OH:5])(=[O:3])[OH:8])=[N:23][CH:22]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11101426HCID 11101426, compound

Product 1

HCID 10469336HCID 10469336, compound

Procedure

1.97 g (4.9 mmol) of 1-(5-methylthiazol-2-ylamino)methane-1,1-diphosphonic acid tetraethyl ester are heated under reflux in 20 ml of N hydrochloric acid for 6 hours. Upon cooling and leaving the reaction mixture to stand at room temperature, the product crystallises. It is filtered and washed with acetone and petroleum ether. Yield: 0.64 g (45% of the theoretical yield) of 1-(5-methylthiazol-2-ylamino)-methane-1,1-diphosphonic acid of m.p. 208° (decomposition).

Workup

  1. temperatureUpon cooling
  2. customleaving the reaction mixture
  3. customto stand at room temperature
  4. customthe product crystallises
  5. filtrationIt is filtered
  6. washwashed with acetone and petroleum ether

Sources & evidence

ORD record
ord-8f7c79d864b74ec2ab48be003423ad8e
Source dataset
uspto-grants-1991_10
Patent number
US05057505

Reaction notes

Loading…