Hydrochloric Acid → HCID 11046323, compound

Participants

Reaction Steps

4.02 g (8.7 mmol) of 1-(5-phenylthiazol-2-yl-amino)methane-1,1-diphosphonic acid tetraethyl ester are heated under reflux in 30 ml of N hydrochloric acid for 18 hours. After cooling to room temperature, a small quantity of methanol is added and the whole is filtered. The filtrate is heated under reflux in methanol for 1 hour, filtered while hot and washed twice with hot methanol. Yield: 2.90 g (95% of the theoretical yield) of 1-(5-phenylthiazol-2-ylamino)methane-1,1-diphosphonic acid of m.p. 290° (decomposition).

Provenance & Evidence