Hydrochloric Acid → HCID 11046323, compound

HRID 345283Notes

Reaction equation

HRID 345283 reaction equation
C([O:3][P:4]([CH:9]([NH:18][C:19]1[S:20][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:22][N:23]=1)[P:10]([O:15]CC)(=[O:14])[O:11]CC)(=[O:8])[O:5]CC)C.Cl>CO>[C:24]1([C:21]2[S:20][C:19]([NH:18][CH:9]([P:10]([OH:14])(=[O:11])[OH:15])[P:4]([OH:8])(=[O:3])[OH:5])=[N:23][CH:22]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11733265HCID 11733265, compound

Product 1

HCID 11046323HCID 11046323, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.02 g (8.7 mmol) of 1-(5-phenylthiazol-2-yl-amino)methane-1,1-diphosphonic acid tetraethyl ester are heated under reflux in 30 ml of N hydrochloric acid for 18 hours. After cooling to room temperature, a small quantity of methanol is added and the whole is filtered. The filtrate is heated under reflux in methanol for 1 hour, filtered while hot and washed twice with hot methanol. Yield: 2.90 g (95% of the theoretical yield) of 1-(5-phenylthiazol-2-ylamino)methane-1,1-diphosphonic acid of m.p. 290° (decomposition).

Workup

  1. filtrationthe whole is filtered
  2. temperatureThe filtrate is heated
  3. temperatureunder reflux in methanol for 1 hour
  4. filtrationfiltered while hot and
  5. washwashed twice with hot methanol

Sources & evidence

ORD record
ord-40132b7d836642db8f23ad90a3576155
Source dataset
uspto-grants-1991_10
Patent number
US05057505

Reaction notes

Loading…