HCID 11037171, compound → HCID 10957767, compound

Participants

Reaction Steps

2.5 g (5.96 mmol) of 1-(benzimidazol-2-ylamino)methane-1,1-diphosphonic acid tetraethyl ester are dissolved in 25 ml of 1N hydrochloric acid and heated at 100°-110° for 26 hours. In the course of the reaction, the product separates out in the form of a fine white precipitate. It is filtered while hot and washed with water and then with methanol. 0.23 g (13% of the theoretical yield) of 1-(benzimidazol-2-ylamino)methane-1,1-diphosphonic acid of m.p. 265° (decomposition) is obtained.

Provenance & Evidence