HCID 11037171, compound → HCID 10957767, compound

HRID 345284Notes

Reaction equation

HRID 345284 reaction equation
C([O:3][P:4]([CH:9]([NH:18][C:19]1[NH:20][C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[N:23]=1)[P:10]([O:15]CC)(=[O:14])[O:11]CC)(=[O:8])[O:5]CC)C>Cl>[N:20]1[C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[NH:23][C:19]=1[NH:18][CH:9]([P:10]([OH:15])(=[O:11])[OH:14])[P:4]([OH:8])(=[O:3])[OH:5]

Participants

3

Reactant 1

HCID 11037171HCID 11037171, compound

Product 1

HCID 10957767HCID 10957767, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2.5 g (5.96 mmol) of 1-(benzimidazol-2-ylamino)methane-1,1-diphosphonic acid tetraethyl ester are dissolved in 25 ml of 1N hydrochloric acid and heated at 100°-110° for 26 hours. In the course of the reaction, the product separates out in the form of a fine white precipitate. It is filtered while hot and washed with water and then with methanol. 0.23 g (13% of the theoretical yield) of 1-(benzimidazol-2-ylamino)methane-1,1-diphosphonic acid of m.p. 265° (decomposition) is obtained.

Workup

  1. temperatureheated at 100°-110° for 26 hours
  2. customIn the course of the reaction
  3. filtrationIt is filtered while hot and
  4. washwashed with water

Sources & evidence

ORD record
ord-6c7bd3ff6f6e40f7bf68c2994ceef1ed
Source dataset
uspto-grants-1991_10
Patent number
US05057505

Reaction notes

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