Sodium Sulfite → HCID 86745159, compound

Participants

Reaction Steps

To a solution of 2'-phenylmethyl-4,5-dihydro-4-oxospiro[1,5-benzothiazepine-2(3H), 1'-cyclohexane] (5.0 g) in methylene chloride (150 ml) was added 80% m-chloroperbenzoic acid (3.9 g) at 0° C. After fifteen minutes, a saturated aqueous solution (150 ml) of sodium sulfite was added to the solution. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residue was triturated with diisopropyl ether to give 2'-phenylmethyl-4,5-dihydro-4-oxospiro[1,5-benzothiazepine-2(3H), 1'-cyclohexane] 1-oxide

Provenance & Evidence