Sodium Sulfite → HCID 86745159, compound

HRID 345302Notes

Reaction equation

HRID 345302 reaction equation
[C:1]1([CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]32[CH2:19][C:18](=[O:20])[NH:17][C:16]2[CH:21]=[CH:22][CH:23]=[CH:24][C:15]=2[S:14]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC1C=CC=C(C(OO)=[O:33])C=1.S([O-])([O-])=O.[Na+].[Na+]>C(Cl)Cl>[C:1]1([CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]32[CH2:19][C:18](=[O:20])[NH:17][C:16]2[CH:21]=[CH:22][CH:23]=[CH:24][C:15]=2[S:14]3=[O:33])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 86745158HCID 86745158, compound

Product 1

HCID 86745159HCID 86745159, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2'-phenylmethyl-4,5-dihydro-4-oxospiro[1,5-benzothiazepine-2(3H), 1'-cyclohexane] (5.0 g) in methylene chloride (150 ml) was added 80% m-chloroperbenzoic acid (3.9 g) at 0° C. After fifteen minutes, a saturated aqueous solution (150 ml) of sodium sulfite was added to the solution. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residue was triturated with diisopropyl ether to give 2'-phenylmethyl-4,5-dihydro-4-oxospiro[1,5-benzothiazepine-2(3H), 1'-cyclohexane] 1-oxide

Workup

  1. waitAfter fifteen minutes
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe residue was triturated with diisopropyl ether

Sources & evidence

ORD record
ord-e53481e3047346538acc77041b533e2a
Source dataset
uspto-grants-1991_10
Patent number
US05057513

Reaction notes

Loading…