HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyl cyanide → 2-Cyano-4-(diethylphosphonomethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | 4-(diethylphosphonomethyl)pyridine-N-oxide | HCID 14541437 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-Cyano-4-(diethylphosphonomethyl)pyridine | HCID 14541438 | — |
Reaction Steps
A mixture of 1.2 g of 4-(diethylphosphonomethyl)pyridine-N-oxide, 1.35 ml of triethylamine and 2.6 ml of trimethylsilylcyanide is heated at 90° for 1 hour. The volatiles are removed in vacuo and the residue is dissolved in ethyl acetate and washed with a small volume of aqueous sodium bicarbonate. After drying over magnesium sulfate the solvent is removed in vacuo to afford 2-cyano-4-(diethylphosphonomethyl)pyridine as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05057506 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-1e89386adf1941feb5daf4c64ecec371 |
| Source note | uspto-grants-1991_10 |