反应详情

A mixture of 1.2 g of 4-(diethylphosphonomethyl)pyridine-N-oxide, 1.35 ml of triethylamine and 2.6 ml of trimethylsilylcyanide is heated at 90° for 1 hour. The volatiles are removed in vacuo and the residue is dissolved in ethyl acetate and washed with a small volume of aqueous sodium bicarbonate. After drying over magnesium sulfate the solvent is removed in vacuo to afford 2-cyano-4-(diethylphosphonomethyl)pyridine as an oil.

1. temperatureis heated at 90° for 1 hour
2. customThe volatiles are removed in vacuo
3. dissolutionthe residue is dissolved in ethyl acetate
4. washwashed with a small volume of aqueous sodium bicarbonate
5. dry with materialAfter drying over magnesium sulfate the solvent
6. customis removed in vacuo