反应详情

A solution of methanesulfonyl chloride (4.84 ml) in 20 ml of methylene chloride is slowly added over 20 minutes to a solution of 8.29 g of 4-hydroxymethylquinoline and 11 ml of triethylamine in 200 ml of methylene chloride at 0°. After completion of the reaction at room temperature, the reaction mixture is partitioned between methylene chloride and saturated potassium carbonate solution. The organic layer is dried over sodium sulfate and evaporated to dryness to yield 4-(methanesulfonyloxymethyl)quinoline as an oil.

1. customAfter completion of the reaction at room temperature
2. customthe reaction mixture is partitioned between methylene chloride and saturated potassium carbonate solution
3. dry with materialThe organic layer is dried over sodium sulfate
4. customevaporated to dryness