HCID 14850786, compound → HCID 86743735, compound

HRID 345324Notes

Reaction equation

HRID 345324 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][C@H:14]([CH2:17][P:18]([O:22][CH3:23])([O:20][CH3:21])=[O:19])[CH2:13][C@@H:12]1[C:24]([OH:26])=[O:25])=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:21][O:20][P:18]([CH2:17][C@H:14]1[CH2:15][CH2:16][NH:11][C@@H:12]([C:24]([OH:26])=[O:25])[CH2:13]1)([O:22][CH3:23])=[O:19]

Participants

4

Reactant 1

HCID 14850786HCID 14850786, compound

Product 1

HCID 86743735HCID 86743735, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

A solution of 1.0 g of cis-1-benzyloxycarbonyl-4-dimethylphosphonomethyl-2-piperidinecarboxylic acid in 30 ml of ethanol is hydrogenated at 3 atmospheres pressure over 500 mg of 10% palladium on carbon catalyst in 30 ml of ethanol. Filtration and removal of solvent affords cis-4-dimethylphosphonomethyl-2-piperidine-carboxylic acid as an amorphous solid.

Workup

  1. filtrationFiltration and removal of solvent

Sources & evidence

ORD record
ord-611350e18b714c378860e1fe5ee2653f
Source dataset
uspto-grants-1991_10
Patent number
US05057506

Reaction notes

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