Hydrochloric Acid → HCID 67887869, compound

HRID 345333Notes

Reaction equation

HRID 345333 reaction equation
C(OC([N:6]1[CH2:10][CH2:9][C@@H:8]([CH2:11][P:12]([O:17]CC)([O:14]CC)=[O:13])[C@@H:7]1[C:20]([O:22]CC)=[O:21])=O)C.[ClH:25]>>[ClH:25].[P:12]([CH2:11][CH:8]1[CH2:9][CH2:10][NH:6][CH:7]1[C:20]([OH:22])=[O:21])([OH:14])([OH:17])=[O:13]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 131716302HCID 131716302, compound

Product 1

HCID 67887869HCID 67887869, compound

Procedure

A solution of 2.7 g of cis and trans ethyl 1-ethoxycarbonyl-3-(diethylphosphonomethyl)pyrrolidine-2-carboxylate is heated under reflux with 6N hydrochloric acid for 6 hours to yield 3-(phosphonomethyl)pyrrolidine-2-carboxylic acid hydrochloride; NMR (D2O): 4.78, 4.40, 3.95, 3.83, 3.72, 3.20, 3.01, 2.78, 2.69 ppm.

Sources & evidence

ORD record
ord-0d21890c620e461f8d8911566d54dcb6
Source dataset
uspto-grants-1991_10
Patent number
US05057506

Reaction notes

Loading…