HCID 14850765, compound → HCID 14850766, compound

HRID 345335Notes

Reaction equation

HRID 345335 reaction equation
Cl.[P:2]([C:6]1[C:7]([C:12]([OH:14])=[O:13])=[N:8][CH:9]=[CH:10][CH:11]=1)([OH:5])([OH:4])=[O:3]>O=[Pt]=O.C(O)(=O)C>[P:2]([CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][CH:7]1[C:12]([OH:14])=[O:13])([OH:4])([OH:5])=[O:3]

Participants

4

Reactant 1

HCID 14850765HCID 14850765, compound

Product 1

HCID 14850766HCID 14850766, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of 348 mg of 3-phosphonopyridine-2-carboxylic acid hydrochloride and 100 mg of Adams catalyst in dilute aqueous acetic acid is hydrogenated at 3 atmospheres pressure and room temperature to yield 3-phosphonopiperidine-2-carboxylic acid, mp 150° dec.

Workup

  1. customis hydrogenated at 3 atmospheres pressure and room temperature

Sources & evidence

ORD record
ord-fad045dd3c43430e8530e45b0ee51f5c
Source dataset
uspto-grants-1991_10
Patent number
US05057506

Reaction notes

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