1-(4-Iodophenyl)-4-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane → 1-[4-(3-Methoxyprop-1-ynyl)phenyl]-4-n-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane

HRID 345371Notes

Reaction equation

HRID 345371 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]23[O:15][CH2:14][C:11]([CH2:16][CH2:17][CH3:18])([CH2:12][O:13]2)[CH:10]([C:19]([F:22])([F:21])[F:20])[O:9]3)=[CH:4][CH:3]=1.[C:23]([C:27]12CO[C:30](C3C=CC(C#CCOC)=CC=3)(OC1)[O:29][CH2:28]2)(C)(C)C>>[CH3:30][O:29][CH2:28][C:27]#[C:23][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[O:13][CH2:12][C:11]([CH2:16][CH2:17][CH3:18])([CH2:14][O:15]2)[CH:10]([C:19]([F:21])([F:22])[F:20])[O:9]3)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 150219591-(4-Iodophenyl)-4-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octaneHCID 150219664-t-Butyl-1-[4-(3-methoxyprop-1-ynyl)phenyl]-2,6,7-trioxabicyclo[2,2,2]octane

Product 1

HCID 150219841-[4-(3-Methoxyprop-1-ynyl)phenyl]-4-n-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane

Procedure

1-[4-(3-Methoxyprop-1-ynyl)phenyl]-4-n-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane was prepared from 1-(4-iodophenyl)-4-n-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane and methyl propargyl ether using the methodology described in Example 3.

Sources & evidence

ORD record
ord-ae8e1fc030ee4d7eabd3a5f55e0a0411
Source dataset
uspto-grants-1991_10
Patent number
US05057508

Reaction notes

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