1-Bromo-4-(trimethoxymethyl)benzene → HCID 18953340, compound

HRID 345375Notes

Reaction equation

HRID 345375 reaction equation
[CH3:1][O:2][C:3]([O:13][CH3:14])([O:11][CH3:12])[C:4]1[CH:9]=[CH:8][C:7](Br)=[CH:6][CH:5]=1.C[C:16](C)(C)[CH2:17][C:18]([CH2:23]O)([CH2:21]O)[CH2:19]O>Cl>[CH3:23][C:18]([CH3:19])([CH3:21])[CH2:17][C:16]12[CH2:14][O:13][C:3]([C:4]3[CH:9]=[CH:8][C:7]([CH2:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:6][CH:5]=3)([O:11][CH2:12]1)[O:2][CH2:1]2

Participants

4

Reactant 2

HCID 135812791-Bromo-4-(trimethoxymethyl)benzeneHCID 189533432-(2,2-Dimethylpropyl)-2-hydroxymethylpropane-1,3-diol

Product 1

HCID 18953340HCID 18953340, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

Trimethyl 4-bromo-orthobenzoate (1.5 g.) (McElvain and Venerable, J. Amer. Chem. Soc., 1950, 72, 1661) was added to 2-(2,2-dimethylpropyl)-2-hydroxymethyl-propan-1,3-diol (1.0 g.). One drop of concentrated hydrochloric acid was added and the mixture was maintained at 140° for one hour, under a current of nitrogen. The volatile components were removed in vacuo (1.0 mm), at 140° C.

Workup

  1. temperaturethe mixture was maintained at 140° for one hour
  2. customThe volatile components were removed in vacuo (1.0 mm), at 140° C.

Sources & evidence

ORD record
ord-c3e3b63b5b7a42beaaf7f452415092de
Source dataset
uspto-grants-1991_10
Patent number
US05057508

Reaction notes

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