1-Methylcyclohexyl 2-amino-alpha-methylbenzothiazole-6-acetate → 1-Adamantyl 2-amino-alpha-methylbenzothiazole-6-acetate

HRID 34542Notes

Reaction equation

HRID 34542 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]([CH3:22])[C:12]([O:14][C:15]3([CH3:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.N[C:24]1[CH:29]=CC(C(C)C(OC23CC4CC(CC(C4)C2)C3)=O)=C[CH:25]=1>>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]([CH3:22])[C:12]([O:14][C:15]34[CH2:21][CH:24]5[CH2:29][CH:19]([CH2:18][CH:17]([CH2:25]5)[CH2:16]3)[CH2:20]4)=[O:13])[CH:8]=[CH:7][C:5]=2[N:6]=1

Participants

3

Reactant 2

HCID 137540721-Methylcyclohexyl 2-amino-alpha-methylbenzothiazole-6-acetateHCID 212981731-Adamantyl 2-(p-aminophenyl)propionate

Product 1

HCID 541685761-Adamantyl 2-amino-alpha-methylbenzothiazole-6-acetateYield 83%

Procedure

Using the methpod similar to that used in the preparation of 1-methylcyclohexyl 2-amino-α-methylbenzothiazole-6-acetate, 19.1 g of 1-adamantyl 2-(p-aminophenyl)propionate were reacted to obtain 18.97 g (83% yield) of 1-adamantyl 2-amino-α-methylbenzothiazole-6-acetate as a creamy white solid melting at 151°-153° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-fcd899a0ea594fffac41dad66a1efbd7
Source dataset
uspto-grants-1988_08
Patent number
US04762840

Reaction notes

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