6-chloro-9-methyl-9H-purine → 6-Chloro-2,9-dimethyl-9H-purine

HRID 345422Notes

Reaction equation

HRID 345422 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:11].N[C:13]1C(Cl)=NC(C)=NC=1NC>>[Cl:1][C:2]1[N:10]=[C:9]([CH3:13])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:11]

Participants

3

Reactant 2

HCID 948446-chloro-9-methyl-9H-purineHCID 150167145-Amino-4-chloro-2-methyl-6-methylaminopyrimidine

Product 1

HCID 150167156-Chloro-2,9-dimethyl-9H-purineYield 97%

Procedure

This was prepared in a manner similar to that described in Example 9 for 6-chloro-9-methylpurine, except that 5-amino-4-chloro-2-methyl-6-methylaminopyrimidine was used as the starting material and the reaction was carried out at 60° C. for 6 hrs. The title compound was obtained in 97% yield.

Workup

  1. customThis was prepared in a manner similar to

Sources & evidence

ORD record
ord-eb2e80a7f8994455ba4a6199d6b59f34
Source dataset
uspto-grants-1991_10
Patent number
US05057517

Reaction notes

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