6-Chloro-2,9-dimethyl-9H-purine → 6-Chloro-2-ethyl-9-methylpurine

HRID 345424Notes

Reaction equation

HRID 345424 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]([CH3:11])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:12].N[C:14]1C(Cl)=NC(CC)=NC=1NC>>[Cl:1][C:2]1[N:10]=[C:9]([CH2:11][CH3:14])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:12]

Participants

3

Reactant 2

HCID 150167156-Chloro-2,9-dimethyl-9H-purineHCID 150168055-Amino-4-chloro-2-ethyl-6-methylaminopyrimidine

Product 1

HCID 150168066-Chloro-2-ethyl-9-methylpurineYield 65%

Procedure

This was prepared in a manner similar to that described in Example 27 for 6-chloro-2,9-dimethylpurine, except that 5-amino-4-chloro-2-ethyl-6-methylaminopyrimidine was used as the starting material, and the final product was purified by chromatography. The title compound was obtained in 65% yield. NMR (CDCl3, δ from TMS): 1.4 (t, CH2CH3), 3.06 (q, CH2CH3), 3.88 (s, NCH3), 8.00 (s, H8).

Workup

  1. customThis was prepared in a manner similar to
  2. customthe final product was purified by chromatography

Sources & evidence

ORD record
ord-1d289f5629d64267a6e5002b80c0f106
Source dataset
uspto-grants-1991_10
Patent number
US05057517

Reaction notes

Loading…