Ethanol → HCID 19992430, compound

HRID 345433Notes

Reaction equation

HRID 345433 reaction equation
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][CH2:7][CH:8]2[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:22][S:23](Cl)(=[O:25])=[O:24].C(O)C>N1C=CC=CC=1>[N:17]1[CH:18]=[CH:19][C:14]([N:11]2[CH2:12][CH2:13][CH:8]([CH2:7][O:6][C:5]3[CH:4]=[CH:3][C:2]([NH:1][S:23]([CH3:22])(=[O:25])=[O:24])=[CH:21][CH:20]=3)[CH2:9][CH2:10]2)=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 31297Methanesulfonyl chlorideHCID 19992424HCID 19992424, compound

Product 1

HCID 19992430HCID 19992430, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Treatment of 4-[(4-aminophenoxy)methyl]-1-[4-pyridyl]piperidine (see Preparation 4) (0.567 g) with methanesulphonyl chloride (0.263 g) in pyridine (18 ml) according to the method of Example 1 gave the title compound, (0.50 g), m.p. 214°-215° (from ethanol).

Sources & evidence

ORD record
ord-e1483b997f774af58453144e1bccc944
Source dataset
uspto-grants-1991_10
Patent number
US05057528

Reaction notes

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