反应详情

A solution of 5.6 g (0.06 mole) of aniline in 50 ml of tetrahydrofuran was added dropwise to a solution of 5.0 g (0.04 mole) of 3-chloropropionyl chloride in 50 ml of tetrahydrofuran. The reaction mixture was mechanically stirred and the temperature maintained between 5° and 15° C. throughout the addition. After the final addition, the solution was filtered to remove solid precipitates, and the filtrate was concentrated under reduced pressure to give a white solid. The solid was recrystallized from benzene and petroleum ether (30°-60° C.) to yield 5.1 g (69%) of white solid, mp 114°-115° C.

1. temperaturethe temperature maintained between 5° and 15° C. throughout the addition
2. additionAfter the final addition
3. filtrationthe solution was filtered
4. customto remove solid
5. customprecipitates
6. concentrationthe filtrate was concentrated under reduced pressure
7. customto give a white solid
8. customThe solid was recrystallized from benzene and petroleum ether (30°-60° C.)