Dimethylamine → HCID 10944045, compound

A solution of 27.5 g (0.610 mole) of dimethylamine in 100 ml of cold tetrahydrofuran was added dropwise to a solution of 25.0 g (0.117 mole) of 6-bromohexanoyl chloride in 100 ml of tetrahydrofuran. The reaction mixture was stirred mechanically and the temperature maintained between 5° and 15° C. throughout the addition. After the final addition, the solution was filtered to remove the solid precipitate and the filtrate was concentrated under reduced pressure to yield 23.3 g (90%) of light-yellow oil. An analytical sample was prepared by filtering the oil through a small bed of silica gel and eluting with ethyl acetate. The fractions containing the desired product were combined and concentrated under reduced pressure to give the title compound as a colorless oil.

1. temperaturethe temperature maintained between 5° and 15° C. throughout the addition
2. additionAfter the final addition
3. filtrationthe solution was filtered
4. customto remove the solid precipitate
5. concentrationthe filtrate was concentrated under reduced pressure

ORD record

ord-ded0816f7d2b41af8d7f84b3ce32cff0

Source dataset

uspto-grants-1991_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05057524