反应详情

To a stirred mixture of 37.8 parts of 4,4-dimethoxy-1-(phenylmethyl)-3-piperidinol and 135 parts of N,N-dimethylformamide were added portionwise 4.8 parts of sodium hydride dispersion 78%. The whole was heated to 60°-70° C. and stirring was continued for 30 minutes at 50° C. After cooling to room temperature, there were added dropwise 18.9 parts of (chloromethyl)benzene (exothermic reaction: temperature roses to 37° C.). Upon completion, stirring was continued for 2 hours at room temperature. The reaction mixture was poured onto 500 parts of water and the product was extracted twice with 1,1'-oxybisethane. The combined extracts were washed with water, dried, filtered and evaporated. The residue was purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (98:2 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was distilled, yielding 33.1 parts (64.6%) of 4,4-dimethoxy-3-(phenylmethoxy)-1-(phenylmethyl)piperidine; bp. 180°-185° C. at 0.3 mm. pressure (intermediate 43).

1. temperatureThe whole was heated to 60°-70° C.
2. stirringUpon completion, stirring
3. waitwas continued for 2 hours at room temperature
4. extractionthe product was extracted twice with 1,1'-oxybisethane
5. washThe combined extracts were washed with water
6. customdried
7. filtrationfiltered
8. customevaporated
9. customThe residue was purified by column-chromatography over silica gel using
10. additiona mixture of trichloromethane and methanol (98:2 by volume) as eluent
11. customThe pure fractions were collected
12. customthe eluent was evaporated
13. distillationThe residue was distilled