Hydrochloric Acid → HCID 19883512, compound

HRID 345562Notes

Reaction equation

HRID 345562 reaction equation
[CH:1]1([C:4](=[O:18])[CH:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.[ClH:19]>>[Cl:19][CH2:3][CH2:2][CH2:1][C:4](=[O:18])[CH:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 132141361-Cyclopropyl-2,2-diphenylethan-1-one

Product 1

HCID 19883512HCID 19883512, compound

Procedure

A mixture of 16 parts of 1-cyclopropyl-2,2-diphenylethanone and 300 parts of hydrochloric acid were stirred and refluxed for 4 hours. The reaction mixture was cooled and extracted with 2,2'-oxybispropane. The extract was washed with water and with a diluted sodium hydrogen carbonate solution, dried, filtered and evaporated, yielding 17 parts of 5-chloro-1,1-diphenyl-2-pentanone as a residue (intermediate 88).

Workup

  1. temperaturerefluxed for 4 hours
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted with 2,2'-oxybispropane
  4. washThe extract was washed with water and with a diluted sodium hydrogen carbonate solution
  5. customdried
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-322415c6618d4c378209f72aa97a4017
Source dataset
uspto-grants-1991_10
Patent number
US05057525

Reaction notes

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