反应详情

A mixture of 16 parts of 1-cyclopropyl-2,2-diphenylethanone and 300 parts of hydrochloric acid were stirred and refluxed for 4 hours. The reaction mixture was cooled and extracted with 2,2'-oxybispropane. The extract was washed with water and with a diluted sodium hydrogen carbonate solution, dried, filtered and evaporated, yielding 17 parts of 5-chloro-1,1-diphenyl-2-pentanone as a residue (intermediate 88).

1. temperaturerefluxed for 4 hours
2. temperatureThe reaction mixture was cooled
3. extractionextracted with 2,2'-oxybispropane
4. washThe extract was washed with water and with a diluted sodium hydrogen carbonate solution
5. customdried
6. filtrationfiltered
7. customevaporated