3,4-Diaminopyridine → HCID 19883518, compound

HRID 345569Notes

Reaction equation

HRID 345569 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH2:7])=[C:3]([NH2:8])[CH:2]=1.[N:9]([CH3:12])=[C:10]=[S:11].O1CCCC1>C(#N)C>[NH2:8][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][C:4]=1[NH:7][C:10]([NH:9][CH3:12])=[S:11]

Participants

5

Reactant 3

HCID 59183,4-DiaminopyridineHCID 8028TetrahydrofuranHCID 11167Methyl isothiocyanate

Product 1

HCID 19883518HCID 19883518, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 4.4 parts of 3,4-pyridinediamine, 4.0 parts of isothiocyanatomethane, 90 parts of tetrahydrofuran and 40 parts of acetonitrile was stirred and refluxed overnight. The reaction mixture was evaporated, yielding 7.3 parts of N-(3-amino-4-pyridinyl)-N'-methylthiourea as a residue (intermediate 95).

Workup

  1. temperaturerefluxed overnight
  2. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-94d582f7a9484ac28ed720eaefbd342f
Source dataset
uspto-grants-1991_10
Patent number
US05057525

Reaction notes

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