Tetrahydrofuran → HCID 15096965, compound

HRID 345570Notes

Reaction equation

HRID 345570 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH:8][C:9]([NH:11][CH3:12])=S.O1CCCC1>[Hg]=O.C(#N)C>[CH3:12][NH:11][C:9]1[NH:1][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][C:7]=2[N:8]=1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 19883518HCID 19883518, compound

Product 1

HCID 15096965HCID 15096965, compound

Reagents, catalysts & solvents 2

HCID 30856Mercuric oxideCatalystHCID 6342AcetonitrileSolvent

Procedure

A mixture of 7.3 parts of N-(3-amino-4-pyridinyl)-N'- methylthiourea, 15 parts of mercury (II)oxide, 90 parts of tetrahydrofuran and 80 parts of acetonitrile was stirred and refluxed for 20 hours. The reaction mixture was filtered hot over Hyflo and the filter-cake was washed with 240 parts of boiling ethanol. The filtrate was evaporated in vacuo and the residue was boiled in acetonitrile. The product was filtered off and dried, yielding 5 parts of N-methyl-3H-imidazo[4,5-c]pyridin-2-amine; mp. 255.7° C. (intermediate 96).

Workup

  1. temperaturerefluxed for 20 hours
  2. filtrationThe reaction mixture was filtered hot over Hyflo
  3. washthe filter-cake was washed with 240 parts of boiling ethanol
  4. customThe filtrate was evaporated in vacuo
  5. filtrationThe product was filtered off
  6. customdried

Sources & evidence

ORD record
ord-27f5937c3a0a45b3b6e3d7d8e57c69cb
Source dataset
uspto-grants-1991_10
Patent number
US05057525

Reaction notes

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