HCID 86743758, compound → HCID 86743757, compound

HRID 345647Notes

Reaction equation

HRID 345647 reaction equation
[Cl:1][CH2:2][CH:3]1[N:6]([S:7]([O-:10])(=[O:9])=[O:8])[C:5](=[O:11])[CH:4]1[NH:12][C:13](=[O:61])[C:14]([C:36]1[N:37]=[C:38]([NH:41]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[S:39][CH:40]=1)=[N:15][O:16]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[NH+]1C=CC=CC=1>C(O)=O>[Cl:1][CH2:2][C@H:3]1[N:6]([S:7]([OH:10])(=[O:8])=[O:9])[C:5](=[O:11])[C@H:4]1[NH:12][C:13](=[O:61])[C:14]([C:36]1[N:37]=[C:38]([NH2:41])[S:39][CH:40]=1)=[N:15][OH:16]

Participants

3

Reactant 1

HCID 86743758HCID 86743758, compound

Product 1

HCID 86743757HCID 86743757, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
60 °C

Procedure

A suspension of 1.02 g of the product of Step B in 9.1 ml of formic acid containing 33% water was heated at 60° C. for 15 minutes and was reacted as in Step C of Example 3 to obtain 119 mg of racemate of syn isomer of cis 4-chloromethyl-3-[2-(2-amino-4-thiazolyl)-2-hydroxyimino-acetamido]-2-oxo-azetidine-1sulfonic acid.

Workup

  1. customwas reacted as in Step C of Example 3

Sources & evidence

ORD record
ord-27308016663846d28e76a704fff1a3e7
Source dataset
uspto-grants-1991_10
Patent number
US05057512

Reaction notes

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