Dimethylformamide → HCID 5327699, compound

HRID 345666Notes

Reaction equation

HRID 345666 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:29])[O:13][C:14](=O)[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH3:25])[C:17]=2[S:26][CH3:27])=[CH:3]1.C[N:31](C=O)C>N>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:29])[NH:31][C:14](=[O:13])[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH3:25])[C:17]=2[S:26][CH3:27])=[CH:3]1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 18780283HCID 18780283, compound

Product 1

HCID 5327699HCID 5327699, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A solution of 804 mg of 3-(1-methyl-3-indolyl)-4-[1-methyl-2-(methylthio)-3-indolyl]furan-2,5-dione in 12 ml of DMF and 50 ml of 33% aqueous ammonia was heated to 130° C. for 2 hours. The product was filtered off and dried to give 675 mg of 3-(1-methyl-3-indolyl)-4-[1-methyl-2-(methylthio)-3-indolyl]-1H-pyrrole-2,5-dione, m.p. 281°-283° C.

Workup

  1. filtrationThe product was filtered off
  2. customdried

Sources & evidence

ORD record
ord-3e9d9d2a8bee439eb225c40b288ec546
Source dataset
uspto-grants-1991_10
Patent number
US05057614

Reaction notes

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