反应详情

150 mg of 3-(1-methyl-3-indolyl)-4-(1-phenyl-3-indolyl)furan-2,5-dione were treated with 3 ml of DMF and 10 ml of 33% aqueous ammonia at 80° C. for 4 hours. The mixture was cooled and extracted with ethyl acetate. The ethyl acetate extract was dried and concentrated. The residue was crystallized from ethyl acetate/hexane to give 120 mg of 3-(1-methyl-3-indolyl)-4-(1-phenyl-3-indolyl)-1H-pyrrole-2,5-dione, m.p. 135°-137° C.

1. temperatureThe mixture was cooled
2. extractionextracted with ethyl acetate
3. extractionThe ethyl acetate extract
4. customwas dried
5. concentrationconcentrated
6. customThe residue was crystallized from ethyl acetate/hexane