Ethylenethiourea → HCID 18780270, Verbindung

HRID 345690Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 345690
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:34])[NH:13][C:14](=[O:33])[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][CH2:26][CH2:27][O:28][S:29]([CH3:32])(=[O:31])=[O:30])[CH:17]=2)=[CH:3]1.[NH:35]1[CH2:39][CH2:38][NH:37][C:36]1=[S:40]>C(O)C>[CH3:32][S:29]([OH:31])(=[O:30])=[O:28].[NH:37]1[CH2:38][CH2:39][N:35]=[C:36]1[S:40][CH2:27][CH2:26][CH2:25][N:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:16]([C:15]2[C:14](=[O:33])[NH:13][C:12](=[O:34])[C:11]=2[C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:2]([CH3:1])[CH:3]=2)=[CH:17]1

Komponenten

4

Edukt 2

HCID 2723650EthylenethioureaHCID 151630513-(1-methyl-3-indolyl)-4-[1-[3-(methylsulphonyloxy)propyl]-3-indolyl]-1H-pyrrole-2,5-dione

Produkt 1

HCID 18780270HCID 18780270, VerbindungAusbeute 27,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

150 mg of the product of Example 58 and 50 mg of 2-imidazolidinethione were heated together at reflux for 24 hours in 5 ml of ethanol. The solvent was evaporated and the residue was chromatographed on silica gel with 10 % to 25% methanol in dichloromethane to give 50 mg of 3-[1-[3-(2-imidazolin-2-ylthio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione methanesulphonate, m.p. 134°-136° C.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue was chromatographed on silica gel with 10 % to 25% methanol in dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-c463dfbfb5d24d8295a8b847737c44e0
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05057614

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