HRID345690

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2723650

4,5-Dihydro-2-mercaptoimidazole

C3H6N2S

结构：Cn1cc(C2=C(c3cn(CCCOS(C)(=O)=O)c4ccccc34)C(=O)NC2=O)c2ccccc21

HCID15163051

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)O.Cn1cc(C2=C(c3cn(CCCSC4=NCCN4)c4ccccc34)C(=O)NC2=O)c2ccccc21

HCID18780270

未命名化合物

收率 27.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

150 mg of the product of Example 58 and 50 mg of 2-imidazolidinethione were heated together at reflux for 24 hours in 5 ml of ethanol. The solvent was evaporated and the residue was chromatographed on silica gel with 10 % to 25% methanol in dichloromethane to give 50 mg of 3-[1-[3-(2-imidazolin-2-ylthio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione methanesulphonate, m.p. 134°-136° C.

WORKUP

后处理

customThe solvent was evaporated
customthe residue was chromatographed on silica gel with 10 % to 25% methanol in dichloromethane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c463dfbfb5d24d8295a8b847737c44e0
来源数据集: uspto-grants-1991_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05057614
来源说明: uspto-grants-1991_10

反应 SMILES

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:34])[NH:13][C:14](=[O:33])[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][CH2:26][CH2:27][O:28][S:29]([CH3:32])(=[O:31])=[O:30])[CH:17]=2)=[CH:3]1.[NH:35]1[CH2:39][CH2:38][NH:37][C:36]1=[S:40]>C(O)C>[CH3:32][S:29]([OH:31])(=[O:30])=[O:28].[NH:37]1[CH2:38][CH2:39][N:35]=[C:36]1[S:40][CH2:27][CH2:26][CH2:25][N:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:16]([C:15]2[C:14](=[O:33])[NH:13][C:12](=[O:34])[C:11]=2[C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:2]([CH3:1])[CH:3]=2)=[CH:17]1