化工社化工社 化学情報印刷レポート · 研究参考用
Ethylenethiourea → HCID 18780270、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylenethiourea | HCID 2723650 | — |
| 反応物 | 3-(1-methyl-3-indolyl)-4-[1-[3-(methylsulphonyloxy)propyl]-3-indolyl]-1H-pyrrole-2,5-dione | HCID 15163051 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 18780270 | HCID 18780270 | 27.5% |
反応手順
150 mg of the product of Example 58 and 50 mg of 2-imidazolidinethione were heated together at reflux for 24 hours in 5 ml of ethanol. The solvent was evaporated and the residue was chromatographed on silica gel with 10 % to 25% methanol in dichloromethane to give 50 mg of 3-[1-[3-(2-imidazolin-2-ylthio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione methanesulphonate, m.p. 134°-136° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05057614 |
| 出典データセット | uspto-grants-1991_10 |
| ORD ID | ord-c463dfbfb5d24d8295a8b847737c44e0 |
| 出典メモ | uspto-grants-1991_10 |