HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 3-amino-2,5-dichloro-4-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Amino-2,5-dichloro-4-methylbenzoic acid | HCID 13657447 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 3-amino-2,5-dichloro-4-methylbenzoate | HCID 13657454 | — |
Reaction Steps
30 g of 3-amino-2,5-dichloro-4-methylbenzoic acid are initially introduced into 140 ml of MeOH. HCl gas is now passed in for 20 minutes and the mixture is then boiled under reflux for a further 5 hours. After cooling, the mixture is poured into water and rendered alkaline with sodium carbonate. The ester which has precipitated is isolated and dried. Yield: 30.8 g, melting point: 53°-55°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762844 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-2edbf5d5bd344535904fb4ffbf640a78 |
| Source note | uspto-grants-1988_08 |