反应详情

30 g of 3-amino-2,5-dichloro-4-methylbenzoic acid are initially introduced into 140 ml of MeOH. HCl gas is now passed in for 20 minutes and the mixture is then boiled under reflux for a further 5 hours. After cooling, the mixture is poured into water and rendered alkaline with sodium carbonate. The ester which has precipitated is isolated and dried. Yield: 30.8 g, melting point: 53°-55°.

1. customis now passed in for 20 minutes
2. temperatureunder reflux for a further 5 hours
3. temperatureAfter cooling
4. customThe ester which has precipitated
5. customis isolated
6. customdried