反应详情

The diazonium salt is heated under dry conditions in a glass flask. When the reaction has ended, the crude methyl 2,5-dichloro-3-fluoro-4-methylbenzoate is taken up in 100 ml of 50% strength EtOH, and 8.2 g of KOH are added. The mixture is boiled under reflux for 1 hour and, after cooling to room temperature, is acidified with HCl. The benzoic acid which has precipitated is isolated, dried and recrystallized from toluene. Yield: 11.3 g, melting point 195°-6°.

1. additionare added
2. temperatureunder reflux for 1 hour
3. customThe benzoic acid which has precipitated
4. customis isolated
5. customdried
6. customrecrystallized from toluene