反应详情

A mixture of 3-(5-trimethylsilyl-3-furyl)propionic acid (61.3 mg, 0.29 mmol), 3-(2,4,5-trifluorophenyl)propan-1-ol (55 mg, 0.29 mmol), 1,3-dicyclohexylcarbodiimide (66 mg, 0.32 mmol) and 4-dimethylaminopyridine (10 mg) in dichloromethane (3 ml) was stirred at room temperature overnight (17 hours). Most of the solvent was evaporated and the residue was purified by preparative TLC (20×20 cm, 1000μ silica plate; developed with 10% ethyl ether/hexane). The title ester was obtained as a colorless oil.

1. customMost of the solvent was evaporated
2. customthe residue was purified by preparative TLC (20×20 cm, 1000μ silica plate; developed with 10% ethyl ether/hexane)