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HRID345903

反应详情

EQUATION

反应方程式

HRID 345903 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CO.Cl
HCID21893726

Hydrochloride methanol

CH5ClO

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
HCID178454152

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CC=C[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C
HCID53845728

未命名化合物

收率 40%

PROCEDURE

实验过程

The 3(R),4(S) diastereomer of Example 5d was deprotected with HCl/methanol, and the resulting product was coupled to Boc-Phe-His using 1-hydroxybenzotriazole and 1,3-dicyclohexylcarbodiimide according to the procedure of Example 5b. The desired product was obtained in 40-60% yield, Mass spectrum: (M+H)+ =628.