HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 53845728, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | HCID 178454152 | HCID 178454152 | — |
| Product | HCID 53845728 | HCID 53845728 | 40% |
Reaction Steps
The 3(R),4(S) diastereomer of Example 5d was deprotected with HCl/methanol, and the resulting product was coupled to Boc-Phe-His using 1-hydroxybenzotriazole and 1,3-dicyclohexylcarbodiimide according to the procedure of Example 5b. The desired product was obtained in 40-60% yield, Mass spectrum: (M+H)+ =628.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05059589 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-a19f238975c740279ca0199139f32a7c |
| Source note | uspto-grants-1991_10 |