HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Fluoro-4-methyl-2-nitrobenzoic acid → 2-Amino-5-fluoro-4-methylbenzoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Fluoro-4-methyl-2-nitrobenzoic acid | HCID 13657449 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 2-Amino-5-fluoro-4-methylbenzoic acid | HCID 13657450 | — |
Reaktionsschritte
525 g of 2-nitro-4-methyl-5-fluoro-benzoic acid are hydrogenated in 3 l of dioxane with 50 g of 5% strength Pd-C catalyst at 30°-40° under 20-30 bar. The catalyst is filtered off with suction and the solution is poured onto water. The crystals which have precipitated are filtered off with suction and dried. Yield: 357 g (80.1% of theory), melting point: 201°-202° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04762844 |
| Quelldatensatz | uspto-grants-1988_08 |
| ORD ID | ord-e46f2afba65f4f8c8a73c8e0d2d83634 |
| Quellennotiz | uspto-grants-1988_08 |