Ethanol → HCID 69991071, compound

HRID 345931Notes

Reaction equation

HRID 345931 reaction equation
[Na].[N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH2:12][O:13][C:14]1[CH:15]=[C:16]([CH:30]=[CH:31][CH:32]=1)[O:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[NH:29][N:28]=[N:27][N:26]=2)=[CH:21][CH:20]=1.[CH2:33]([O:35][C:36](=[O:39])CBr)[CH3:34].[CH2:40](O)C>>[CH3:40][CH2:34][CH2:33][O:35][C:36]([N:27]1[N:26]=[C:25]([C:22]2[CH:23]=[CH:24][C:19]([CH2:18][O:17][C:16]3[CH:30]=[CH:31][CH:32]=[C:14]([O:13][CH2:12][C:3]4[CH:4]=[CH:5][C:6]5[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=5)[N:2]=4)[CH:15]=3)=[CH:20][CH:21]=2)[N:29]=[N:28]1)=[O:39]

Participants

5

Reactant 4

HCID 702EthanolHCID 7748Ethyl bromoacetateHCID 5360545SodiumHCID 178420709HCID 178420709, compound

Product 1

HCID 69991071HCID 69991071, compound

Procedure

To a solution of 0.2 g sodium in 30 ml ethanol is first added 1 g of 5-(4-(3-(2-quinolinylmethyloxy)phenoxymethyl)phenyl)tetrazole and then after 30 minutes 0.6 g of ethylbromoacetate and stirring is continued at 80° C. for 16 hours. The solvent is then removed, diluted with water, filtered, washed with ether and dried to give the desired compound, also referred to as ethyl 5-(4-(3-(2-quinolinylmethyloxy)phenoxymethyl)phenyl)tetrazole-3-yl acetate.

Workup

  1. customThe solvent is then removed
  2. additiondiluted with water
  3. filtrationfiltered
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-444bed51fc36405a92252014d7800238
Source dataset
uspto-grants-1991_10
Patent number
US05059610

Reaction notes

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