Dimethylformamide dimethyl acetal → HCID 15042092, compound

HRID 345945Notes

Reaction equation

HRID 345945 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]3[N:14]=[CH:15][C:16]([C:17]([NH2:19])=[O:18])=[C:12]3[N:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.CO[CH:22](OC)[N:23]([CH3:25])[CH3:24]>>[CH3:22][N:23]([CH:25]=[N:19][C:17]([C:16]1[CH:15]=[N:14][N:13]2[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=3)=[CH:9][CH:10]=[N:11][C:12]=12)=[O:18])[CH3:24]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 15042086HCID 15042086, compound

Product 1

HCID 15042092HCID 15042092, compound

Procedure

A mixture of 6.0 g of 7-(3-methylphenyl) pyrazolo(1,5-a)pyrimidine-3-carboxamide (Example 13) and 15 ml of N,N-dimethylformamide dimethyl acetal is heated on a steam bath for 4 hours to give a solution. The solution is evaporated in vacuo to give a solid. The solid is recrystallized twice from dichloromethane-hexane to give 4.70 g of the desired product as colorless crystals, mp 165°-166° C.

Workup

  1. temperatureis heated on a steam bath for 4 hours
  2. customto give a solution
  3. customThe solution is evaporated in vacuo
  4. customto give a solid
  5. customThe solid is recrystallized twice from dichloromethane-hexane

Sources & evidence

ORD record
ord-4b29632e4c024581bddae5a7c304961f
Source dataset
uspto-grants-1991_10
Patent number
US05059691

Reaction notes

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