1,1-Dimethoxyethyl(dimethyl)amine → HCID 57239178, compound

HRID 345948Notes

Reaction equation

HRID 345948 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([NH2:18])=[O:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.CO[C:21](OC)([N:23]([CH3:25])[CH3:24])[CH3:22]>>[CH3:24][N:23]([CH2:21][CH:22]=[N:18][C:16]([C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12)=[O:17])[CH3:25]

Participants

3

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 145018627-(Pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Product 1

HCID 57239178HCID 57239178, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 10.0 g of 7-(3-pyridinyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide (prepared as described in Example 9) and 50.0 ml of N,N-dimethylacetamide dimethyl acetal are heated at 120° C. for 2 hours. After cooling, the reaction mixture is evaporated in vacuo to give an oil. The oil is triturated with diethyl ether to separate a yellow solid. The solid is collected by filtration, washed with ether, air dried, then dried in vacuo to give 12.37 g of the desired product as a tan solid, mp 124°-127° C.

Workup

  1. temperatureAfter cooling
  2. customthe reaction mixture is evaporated in vacuo
  3. customto give an oil
  4. customThe oil is triturated with diethyl ether
  5. customto separate a yellow solid
  6. filtrationThe solid is collected by filtration
  7. washwashed with ether, air
  8. customdried
  9. customdried in vacuo

Sources & evidence

ORD record
ord-c9cf8e1ed89348449613b14c850ac85b
Source dataset
uspto-grants-1991_10
Patent number
US05059691

Reaction notes

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