Morpholine → HCID 19991746, compound

HRID 345989Notes

Reaction equation

HRID 345989 reaction equation
Cl[C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([N:9]2[C:14]([CH3:16])([CH3:15])[CH2:13][CH:12]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:11][C:10]2([CH3:25])[CH3:24])[N:3]=1.[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>O>[O:29]1[CH2:30][CH2:31][N:26]([C:2]2[N:7]=[C:6]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)[N:5]=[C:4]([N:9]3[C:14]([CH3:16])([CH3:15])[CH2:13][CH:12]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:11][C:10]3([CH3:25])[CH3:24])[N:3]=2)[CH2:27][CH2:28]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 19991788HCID 19991788, compound

Product 1

HCID 19991746HCID 19991746, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9.7 g of the product from Example 10 are heated under reflux for 3 hours with 50 ml of morpholine. The orange reaction mixture is poured into water. The crude product precipitating during this is dissolved in ethyl acetate and purified chromatographically on an SiO2 column. The purified product is a viscous material.

Workup

  1. customThe crude product precipitating during
  2. dissolutionthis is dissolved in ethyl acetate
  3. custompurified chromatographically on an SiO2 column

Sources & evidence

ORD record
ord-47e8bebedc6d4f928ef3e9a96362b9b9
Source dataset
uspto-grants-1991_10
Patent number
US05059689

Reaction notes

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