HCID 19991750, compound → HCID 19991757, compound

HRID 345993Notes

Reaction equation

HRID 345993 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([N:19]3[C:24]([CH3:26])([CH3:25])[CH2:23][C:22](=[O:27])[CH2:21][C:20]3([CH3:29])[CH3:28])[N:8]=2)[CH2:3][CH2:2]1>O1CCCC1.[Ni]>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[N:12]=[C:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[N:10]=[C:9]([N:19]3[C:20]([CH3:28])([CH3:29])[CH2:21][CH:22]([OH:27])[CH2:23][C:24]3([CH3:26])[CH3:25])[N:8]=2)[CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 19991750HCID 19991750, compound2×

Product 1

HCID 19991757HCID 19991757, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

5 g of 2,4-dimorpholino-6-(4-oxo-2,2,6,6-tetramethylpiperidin-1-yl)-1,3,5-triazine (product from Example 21) are hydrogenated in 100 ml of tetrahydrofuran at 60° and a pressure of 100 bar until the reaction stops using Raney nickel as the catalyst. The reaction mixture is filtered, the solution is evaporated and the residue is recrystallized from 20 ml of toluene. The above substance is produced as white crystals which melt at 202°-204°.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe solution is evaporated
  3. customthe residue is recrystallized from 20 ml of toluene
  4. customThe above substance is produced as white crystals which
  5. custommelt at 202°-204°

Sources & evidence

ORD record
ord-384518fff2c54e95bb9c21dff0ff12ab
Source dataset
uspto-grants-1991_10
Patent number
US05059689

Reaction notes

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