反应详情

A mixture of 2-[4-(prop-2-yn-1-yl)-2,3,5,6-tetrafluorobenzyloxy]tetrahydropyran (0.8 g), dilute hydrochloric acid (2N, 5 cm3) and methanol (30 cm3) was stirred together at the ambient temperature for 2 hours, after which the more volatile portion was removed by evaporation under reduced pressure. The residue was extracted with diethyl ether, the extracts combined, washed with water, and dried over anhydrous magnesium sulphate. Removal of the solvent by evaporation under reduced pressure yielded an oil which crystallised on standing to give 4-(prop-2-yn-1-yl)-2,3,5,6-tetrafluorobenzyl alcohol (0.5 g), m.p. 51°-52° C., after recrystallisation from petroleum ether (boiling range 60°-80° C.).

1. customafter which the more volatile portion was removed by evaporation under reduced pressure
2. extractionThe residue was extracted with diethyl ether
3. washwashed with water
4. dry with materialdried over anhydrous magnesium sulphate
5. customRemoval of the solvent
6. customby evaporation under reduced pressure
7. customyielded an oil which
8. customcrystallised