Phenol → HCID 19600830, compound

HRID 346014Notes

Reaction equation

HRID 346014 reaction equation
C1([OH:7])C=CC=CC=1.[OH:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14][CH3:15])=[O:13].[CH2:19]([O:26][C:27]1[CH:28]=[CH:29][C:30]2[O:36][CH2:35][CH2:34][CH:33](Br)[CH2:32][C:31]=2[CH:38]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([O:26][C:27]1[CH:28]=[CH:29][C:30]2[O:36][CH2:35][CH2:34][CH:33]([O:8][C:9]3[CH:18]=[CH:17][CH:16]=[C:11]([C:12]([O:14][CH3:15])=[O:13])[CH:10]=3)[C:32](=[O:7])[C:31]=2[CH:38]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 996PhenolHCID 88068Methyl 3-HydroxybenzoateHCID 86745185HCID 86745185, compound

Product 1

HCID 19600830HCID 19600830, compound

Procedure

By the method of Example 27, substituting the phenol with a molar equivalent of methyl 3-hydroxybenzoate, 7-benzyloxy-4-bromo-3,4-dihydro-1-benzoxepin-(5(2H)-one (17.3 g) was converted to present title product, 10.9 g, m.p. 134°-136° C.

Sources & evidence

ORD record
ord-20660eca6d224407ab3ab1302d875410
Source dataset
uspto-grants-1991_10
Patent number
US05059609

Reaction notes

Loading…