HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 6-Benzyloxy-3-methylene-4-chromanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 6-(Benzyloxy)chroman-4-one | HCID 14422776 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Benzyloxy-3-methylene-4-chromanone | HCID 14422790 | — |
Reaction Steps
A solution of 9.2 g of 6-benzyloxy-4-chromanone, dimethylamine hydrochloride and 1.3 g of paraformaldehyde in 100 ml of acetic acid was heated on a steam bath for 5 hours. The volatiles were evaporated in vacuo and the residue was purified on silica gel, eluting with CH2Cl2, to give 3.7 g of product, Rf (CH2Cl2)=0.5. 1H-NMR(CDCl3)delta(ppm): 4.95 (s, 2H), 5.05 (s, 2H), 5.55 (s, 1H), 6.30 (s, 1H), 6.80-7.60 (m, 8H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05059609 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-2d03639bc0e640f2989953836a2f30a6 |
| Source note | uspto-grants-1991_10 |