Methyl iodide → HCID 19990236, compound

HRID 346077Notes

Reaction equation

HRID 346077 reaction equation
FC(F)(F)[C:3]([NH:5][C:6]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][N:8]([CH3:14])[N:7]=1)=O.CI.[OH-].[K+]>CC(C)=O>[CH3:14][N:8]1[CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:6]([NH:5][CH3:3])=[N:7]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 199902422,2,2-Trifluoro-N-(1-methyl-4-nitro-1H-pyrazol-3-yl)acetamide

Product 1

HCID 19990236HCID 19990236, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

100 g (4.20 mmoles) of 3-trifluoroacetylamino-1-methyl-4-nitropyrazol are heated with 2.12 g (16.8 mmoles) methyl iodide in 10 ml absolute acetone to 50° C. 940 mg (16.8 mmoles) powdered potassium hydroxide are then added and the reaction mixture is heated to boiling for 5 minutes. The solvent is distilled off in the rotary evaporator in vacuum and the residue is separated by means of column chromatography using silica gel with ether/toluene (5:1).

Workup

  1. additionare then added
  2. temperaturethe reaction mixture is heated
  3. distillationThe solvent is distilled off in the rotary evaporator in vacuum
  4. customthe residue is separated by means of column chromatography

Sources & evidence

ORD record
ord-b5a7cbd289cb4d4c8494d165fb3217cd
Source dataset
uspto-grants-1991_10
Patent number
US05061289

Reaction notes

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