HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 19990236, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2,2,2-Trifluoro-N-(1-methyl-4-nitro-1H-pyrazol-3-yl)acetamide | HCID 19990242 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 19990236 | HCID 19990236 | — |
Reaction Steps
100 g (4.20 mmoles) of 3-trifluoroacetylamino-1-methyl-4-nitropyrazol are heated with 2.12 g (16.8 mmoles) methyl iodide in 10 ml absolute acetone to 50° C. 940 mg (16.8 mmoles) powdered potassium hydroxide are then added and the reaction mixture is heated to boiling for 5 minutes. The solvent is distilled off in the rotary evaporator in vacuum and the residue is separated by means of column chromatography using silica gel with ether/toluene (5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05061289 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-b5a7cbd289cb4d4c8494d165fb3217cd |
| Source note | uspto-grants-1991_10 |