反应详情

In 4 ml of dichloromethane were dissolved 50 mg of (2R,4R)-2-(4-hydroxyphenyl)-4-decanolide obtained in Example 3 and 49 mg of 4-octyloxybenzoyl chloride. To this solution was added 1 ml of pyridine. The resulting mixture was stirred for 6 hours under heating to reflux. The reaction mixture was allowed to cool, and then 50 ml of ether and diluted hydrochloric acid were added thereto. The resulting organic layer was separated, washed with water, and then dried with anhydrous sodium sulfate. The solvent was removed by evaporation and the resulting crude produce was purified by silica gel column chromatography, thereby obtaining 65 mg of crystals of the desired compound (yield 70%).

1. temperatureunder heating to reflux
2. temperatureto cool
3. customThe resulting organic layer was separated
4. washwashed with water
5. dry with materialdried with anhydrous sodium sulfate
6. customThe solvent was removed by evaporation
7. customthe resulting crude produce
8. customwas purified by silica gel column chromatography